Ein Unglück entzweite einst zwei Halbgeschwister. Nun laufen sie sich bei einem Modelabel über den Weg – aber einer sinnt auf Rache, ohne dass die andere davon weiß.
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Bernadette "Detty" Sabroso is the daughter of wealthy silk factory owners, Raphael and Kara Sabroso. Raphael also has an illegitimate son, Bernardo "Totoy", with his former maid, Maria Laurel. Raphael takes Maria and Bernard in when they have nowhere else to go. Unaware of their sibling relationship, Bernardo and Bernadette become close friends like sisters due to their shared love for fashion. When Kara discovers Raphael's affair with Maria and learns that Bernard is his son, she confronts them, kicks them out, and accidentally paralyzes Maria by pushing her down the stairs. Bernard, receiving no assistance from the family or the maids, swears vengeance against the family of Sabrosos. 25 Years later, Detty and Totoy, now known as Bernice, lead very different lives. Detty struggles financially after her tailor shop goes bankrupt and fights for custody of her children, Kathy and Cindy, from her ex-husband. Meanwhile, Bernice runs the successful, wealthy fashion brand Ponytale and lives in a luxury estate with his mother Maria and Angelo, the son of Bernice's deceased former maid. Unaware of their sibling relationship, Detty applies for a job at Ponytale. Bernice, seeing an opportunity for revenge, hires her and assigns her absurd and embarrassing tasks. He also encourages Angelo, who also goes to the same school as Kathy, to date and then break up with Kathy to hurt her, as Kathy had previously humiliated him earlier at school. Despite the odd duties, Detty completes her tasks without complaint. As Bernice begins to doubt his vengeful plans, his mother advises him to continue. At the Run Away Fashion Show, Bernice confronts his rival, Roselle Hermosa, who owns the competing brand La Yondelle and is vying for a European partnership deal. La Yondelle's collection is revealed to be stolen from Ponytale, prompting Detty to revise the fashion line quickly. The revamped collection is successful, but Bernice, upset over the stolen designs, fails to thank Detty for saving the brand. Frustrated, Detty tries to resign, but Bernice persuades her to stay by raising her salary and increasing her work benefits. Roselle hires Brazilian Filipino model Marlon as her brand's endorser and asks Bernice's design partner James, who is a mole in Ponytale, to convince Detty to join La Yondelle. Detty helps Marlon with a flat tire and escorts him to a hotel, where Bernice and Roselle argue over him. Marlon signs with Ponytale with Detty's assistance, and they begin to show interest in each other. At Bernice's house, Detty twists her ankle, and Marlon massages it, but Bernice misinterprets the situation and fires Marlon. Bernice and Maria confront Detty about their past family Sabroso, Kara Sabroso, and Maria reenact her fall to help Detty remember her was a half-sibling and the younger son of Raphael. Detty begs for forgiveness from her gay half-brother, but Bernice fires her. Back home, Detty tells Kathy that her boss is her brother. Later, the siblings confront each other, and Bernice reveals that he used Angelo, who now has feelings for Kathy, as part of his revenge family. At school, Angelo approaches Kathy to explain that he went through with Bernice's plan because he owes him for taking him in and that he really loves her. Roselle and James convince Detty to join La Yondelle. Bernice confronts them, where he realizes that James was the mole, and despite negotiations from him, Detty decides to remain at La Yondelle. Bernice devises an elaborate plan to scare Roselle with two employees in a costume of ghostly flower girl (a parody of Sukob) and Lotus Feet (a parody of Feng Shui), which causes her to fall a flight of stairs and fracture her foot, and the latter vows revenge against Ponytale, (after finding a security footage of Bernice), which is facing dwindling sales. Bernice's close friend Jessie advises him to get back Detty and forget about his revenge scheme if he wants Ponytale to emerge successful. After a failed attempt at reconciliation with his sister, Bernice tells his mother that he wants to stop his revenge scheme and that nothing good will come out of it. Roselle's father, Simon, wants Detty to replace Roselle. James persuades Roselle to eliminate Detty. Later, Detty, Kathy, and Cindy are taken to an abandoned warehouse, with Bernice and Angelo in pursuit. Detty's family is ambushed by Roselle, James, and thugs, but Roselle, along with her other two assistants has a change of heart after seeing Detty willing to protect her children, who convinced them not to kill their mother and asks James to stop. Refused, James tries to kill Roselle to take over La Yondelle himself, but Bernice, arriving with Angelo and the police, intervenes and takes a bullet for Detty. Totoy was bullet wounded by James. At the hospital, the siblings reconcile. Bernice recovers after a now redeemed Roselle donates her blood and makes amends. Angelo decides to pursue Kathy again. In a fashion runway event, Detty becomes co-president at Ponytale, and she and Bernice team up with Roselle to create a new fashion line, "Sisterakas."
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